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Psoriasis and Gut-Skin Connection in New York, NY: Insights from Dr. Gary Jayne Rothfeld at 629 Park Ave

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Psoriasis and the Gut-Skin Connection in New York, NY: A Groundbreaking Insight by Dr. Gary Jayne Rothfeld at 629 Park Ave


 

The connection between the gut and the skin is more than just a scientific curiosity; it’s a revelation that’s slowly but surely changing how we understand and treat psoriasis. As with all complex health conditions, psoriasis doesn’t play by simple rules. What we’ve known for years—essentially that it’s a genetic autoimmune condition—is no longer enough to explain why one person’s psoriasis flares while another’s remains dormant. The answer, my friends, may lie deeper than just the skin itself.


 

It turns out, the gut, often dismissed as the mere organ responsible for digesting your lunch, is quite the player in this skin drama. The microbiome—the intricate community of bacteria, fungi, and other microorganisms residing in your gut—has more to do with your psoriasis than you might think. And no, it’s not just another passing health trend; this is the kind of science that could change how we approach the disease entirely.


 

The Science of the Gut-Skin Axis

Now, before we get lost in the weeds of microbiota and cytokines, let’s take a moment to appreciate the brilliance of the human body. When psoriasis strikes, the immune system mistakenly signals skin cells to proliferate faster than they should. This leads to the characteristic patches of inflamed, scaly skin. What’s emerging now, however, is the understanding that the gut can influence this response.

The relationship between the gut and skin is known as the gut-skin axis. Research is increasingly showing that an imbalance in the gut microbiome—a condition known as dysbiosis—may contribute to inflammatory skin diseases like psoriasis. Essentially, when your gut is out of balance, your immune system gets the wrong signals, and boom, your psoriasis flares.

How does this work? Well, a disrupted microbiome can trigger systemic inflammation, which has a direct impact on the skin. The gut houses over 70% of your immune system, so any disturbance here can set off a cascade of reactions. It’s no longer just about what you put on your skin—it’s about what’s going on inside your body. Diet, probiotics, and overall gut health are being studied as potential avenues to reduce flare-ups and even prevent psoriasis from manifesting in the first place.

From Pizza to Probiotics: The Impact of Diet

Now, let’s talk about diet. Sure, you can always blame a pizza for your flare-up, but let’s dig a little deeper than mere indulgence. Studies have suggested that certain dietary factors, like high sugar, excessive alcohol, and inflammatory foods, may trigger or exacerbate psoriasis. But, and this is key, healthy choices might help reverse that trend.

Enter probiotics. These little warriors are the champions of gut health. If your gut microbiome is the conductor of your immune system orchestra, then probiotics are the instruments you need to play a harmonious tune. They help replenish good bacteria, restore balance, and reduce inflammation—potentially leading to fewer psoriasis flare-ups.

While research is still evolving, the link between the gut microbiome and psoriasis management is becoming undeniable. I encourage you to explore dietary changes and supplements under the guidance of a qualified healthcare professional—because treating psoriasis isn’t just about suppressing the symptoms. It's about tackling the root causes, and your gut may hold the key.

Dr. Gary Jayne Rothfeld: A New Era in Psoriasis Care at 629 Park Avenue, New York

Dr. Gary Jayne Rothfeld is a highly respected board-certified dermatologist with over four decades of experience in the field of skin health. Known for his innovative approaches to dermatologic treatments, Dr. Rothfeld has garnered a reputation as one of New York’s top dermatologists, combining cutting-edge medical knowledge with a deeply personalized patient care philosophy.

In addition to his clinical expertise, Dr. Rothfeld is a prolific writer and lecturer, sharing his insights with medical professionals and the public alike. His work has been published in numerous prestigious medical journals, and he is often invited to speak at dermatology conferences worldwide. Dr. Rothfeld’s expertise is sought after by Hollywood’s elite, who rely on him for advanced skincare and cosmetic treatments.

Dr. Rothfeld is also an accomplished athlete, competing as a senior swimmer in the Senior Olympics, where his commitment to health and wellness extends beyond his professional work. This unique combination of medical brilliance, celebrity expertise, and athletic discipline has made Dr. Rothfeld a highly regarded figure in both the medical and entertainment worlds.

As a dermatologist with extensive experience, Dr. Rothfeld is continuously at the forefront of new research in psoriasis treatment. The exploration of the gut-skin connection marks a pivotal moment in the evolution of psoriasis care, and Dr. Rothfeld is eager to integrate these groundbreaking discoveries into his practice at 629 Park Avenue in New York, NY.

The Road Ahead: A Holistic Approach to Psoriasis Treatment in New York, NY

Psoriasis is a complex condition, and understanding the full scope of its triggers and treatments is essential for managing it effectively. The gut-skin connection is just the beginning, but it represents the future. By incorporating dietary changes, probiotic-rich foods, and a focus on gut health, we can take a more comprehensive approach to treating psoriasis—one that’s not just about managing flare-ups but about preventing them altogether.

So, the next time you reach for a yogurt or make a decision about what’s going into your body, remember: you might just be doing your skin a favor. Keep an open mind, and embrace the emerging science of the gut-skin connection. Your skin will thank you.


DR GARY JAYNE ROTHFELD

#1 Hair Loss Doctor Dr. Gary Jayne Rothfeld Presents VDPHL01 – The Future of Non-Hormonal Hair Restoration

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VDPHL01: A Bold New Chapter in the Fight Against Hair Loss

Imagine a world where your receding hairline isn’t a lifelong curse but merely a temporary setback—one that can be challenged with a pill that shuns hormonal shortcuts. Enter VDPHL01, the non‐hormonal oral treatment under clinical investigation for androgenetic alopecia, poised to rewrite the narrative of hair restoration.

Rethinking Hair Loss

For too long, the arsenal against hair loss has been dominated by treatments that, while effective, often come with unwanted baggage. Traditional drugs work through hormonal pathways that can leave you with side effects that make you question whether you’re treating your hair loss or trading one set of problems for another. VDPHL01 dares to take a different route. It’s not about manipulating your hormones—it’s about empowering your hair follicles directly, with a mechanism that promises growth without the collateral damage.

The Science Behind the Promise

VDPHL01 is engineered to be taken once or twice a day, with early Phase 2 data suggesting that hair growth can be observed as early as two months into treatment. This pill sidesteps the pitfalls of conventional therapies by not interfering with the delicate hormonal balance. Instead, it works by targeting cellular pathways that stimulate hair regeneration, all while avoiding the notorious side effects associated with hormonal treatments. In other words, if your current treatment feels like a high-stakes gamble, VDPHL01 is emerging as a safer bet.

Expert Insight: Dr. Gary Jayne Rothfeld

Adding weight to this innovative approach is Dr. Gary Jayne Rothfeld, a board-certified dermatologist celebrated as one of the top hair loss doctors in NYC, the U.S., and globally. With over 40 years of experience and a reputation built on amazing results in both non-surgical and surgical therapies—including treating elite athletes—Dr. Rothfeld has long championed methods that empower the body’s natural regenerative processes. His insights echo the promise of VDPHL01: a shift away from traditional, hormone-dependent treatments toward strategies that truly respect and harness your body’s inherent potential.

Clinical Trials: Numbers and Nuance

The clinical trial for VDPHL01 is nothing short of ambitious. With around 480 male participants enrolled across 44 U.S. sites, the study is designed to rigorously test the pill’s safety and efficacy. The trial’s scale is a testament to the promise VDPHL01 holds; it’s not a niche experiment but a full-throttle attempt to tackle one of the most common yet stubborn conditions affecting millions. And the plan doesn’t stop with men—there’s a roadmap for including women in later phases, hinting at a future where hair loss treatment is as inclusive as it is innovative.

A Dose of Reality

Let’s be honest: hair loss has always been a subject ripe for both despair and dark humor. There’s an unspoken irony in watching elite athletes and everyday heroes alike battle the same condition. VDPHL01 enters the scene with a refreshing mix of science and pragmatism—offering hope without promising miracles. It’s the kind of treatment that doesn’t sugarcoat the reality: regrowth takes time, consistency is key, and no pill is a magic bullet. Yet, in a field too often dominated by dramatic claims and inflated expectations, a modest, evidence-based approach might just be the breakthrough we need.

Why It Matters

Hair is more than just a style—it’s an identity, a statement of self. For many, hair loss isn’t merely a cosmetic issue; it’s a blow to confidence and self-image. VDPHL01, with its non-hormonal design and promising early results, represents not just a new treatment option but a paradigm shift. It’s a chance to reclaim a part of yourself that society often tells you is destined to fade away.

Looking Ahead

As the clinical trials progress, the dermatology community watches with cautious optimism. Should VDPHL01 continue to deliver on its early promise, it may well become a cornerstone in the modern treatment of hair loss—offering a fresh, scientifically grounded alternative that’s as effective as it is safe.

In a landscape where every new treatment is scrutinized and every claim questioned, VDPHL01 stands out by daring to be different. Coupled with the endorsement and expertise of Dr. Gary Jayne Rothfeld, this treatment invites us to reimagine what hair restoration could be: less about playing with hormones and more about unlocking your body’s own regenerative potential.

Stay tuned as we follow the journey of VDPHL01—a bold new chapter in the fight against hair loss that might just turn the tide for millions.

 

DR GARY JAYNE ROTHFELD

Ehlers-Danlos Syndrome (Cutis Hyperelastica) and Aortic Dissection: A Comprehensive Review by Dr. Gary Jayne Rothfeld

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Ehlers-Danlos Syndrome (Cutis Hyperelastica) and Aortic Dissection: A Detailed Insight by Dr. Gary Jayne Rothfeld

Ehlers-Danlos Syndrome (EDS) represents a complex and multifaceted group of genetic disorders characterized by defects in connective tissue, the body’s structural framework. Of particular interest to the discerning dermatologist and clinician is Cutis Hyperelastica, a variant of EDS that manifests prominently in the skin, which is hyper-elastic, fragile, and prone to trauma.

As practitioners who specialize in the nuances of dermatological care, we must recognize the interconnectivity of EDS with other systemic conditions, most notably Aortic Dissection. This article, presented by Dr. Gary Jayne Rothfeld, seeks to explore the intricate relationship between Ehlers-Danlos Syndrome and Aortic Dissection, with an emphasis on the dermatological and vascular considerations integral to managing patients with these overlapping concerns.

Understanding Ehlers-Danlos Syndrome: A Dermato-Vascular Paradigm

Ehlers-Danlos Syndrome (EDS) is a rare, inherited disorder that primarily affects the collagen and elastin in the body, two key structural components of connective tissue. The disease manifests in various forms, depending on the genetic mutation involved. One of the most distinctive and clinically notable variants is Cutis Hyperelastica, often presenting with hyper-elastic skin that exhibits an excessive range of motion. The skin may appear smooth, soft, and velvety, with an ability to stretch significantly beyond normal limits, which distinguishes it from other skin conditions.

While the skin presents as the most visually apparent manifestation, the systemic involvement in EDS—particularly vascular EDS—presents a grave and often life-threatening risk. The Aortic Dissection seen in these individuals is a direct result of the weakening and abnormal collagen found within the vascular walls.

Cutis Hyperelastica and the Dermatological Evaluation

Patients with Cutis Hyperelastica commonly present with skin that demonstrates an exceptional degree of elasticity. Clinicians should note the following key features:

  • Hyper-elasticity of the Skin: The skin can be stretched significantly, but it may also appear abnormally thin, fragile, and prone to bruising and scarring.
  • Joint Hypermobility: Patients may exhibit hypermobile joints, leading to frequent dislocations or subluxations.
  • Atrophic Scarring: Despite the remarkable flexibility of the skin, wounds and cuts may heal poorly, often leaving scars that appear thin, elongated, or atrophic.

In addition to dermatological findings, patients may present with vascular manifestations, especially in forms of EDS that involve mutations affecting collagen synthesis, such as vascular EDS (types IV). These patients are at an elevated risk of developing Aortic Dissection.

Aortic Dissection: A Vascular Complication in Ehlers-Danlos Syndrome

Aortic dissection is a catastrophic event, wherein a tear develops in the inner layer of the aortic wall, allowing blood to flow between the layers of the vessel. This is an emergent condition that can lead to rupture or reduced blood flow to vital organs, often resulting in death if not treated promptly.

In patients with Ehlers-Danlos Syndrome, the primary defect lies in the abnormal structure and function of collagen, a fundamental component of the vascular walls. The aorta, being the largest artery in the body, is particularly vulnerable. The following are key features of Aortic Dissection in the context of Ehlers-Danlos Syndrome:

  • Hyper-elastic Vascular Walls: Collagen defects lead to vascular fragility, predisposing patients to the formation of aneurysms or dissections.
  • Risk Factors for Aortic Dissection: High blood pressure, trauma, and a rapid increase in arterial pressure can exacerbate this risk in patients with EDS.
  • Symptoms: Patients may present with severe chest pain, back pain, or symptoms consistent with a stroke, including sudden weakness or difficulty speaking.

Vascular EDS (a subtype) is specifically linked with increased risks of aortic dissection due to the compromised connective tissue in the aortic wall. Timely diagnosis and intervention are critical, including cardiovascular imaging such as CT angiography or MRI to assess the aorta’s integrity.

Clinical Management and Multidisciplinary Approach

Management of patients with Ehlers-Danlos Syndrome (Cutis Hyperelastica) requires a multidisciplinary approach, given the complexity of the disease. Below are key considerations:

1. Dermatological Management:

  • Skin Care: Due to the fragile nature of the skin, it is essential to provide gentle care, avoiding trauma that could lead to scarring or delayed healing.
  • Monitoring: Regular skin checks for signs of trauma, infections, or unusual scarring should be undertaken. Patients may benefit from specialized dermatological treatments that improve skin elasticity.

2. Cardiovascular Management:

  • Regular Monitoring: Patients with vascular EDS should undergo regular cardiovascular screening, including imaging studies to monitor for aortic dilation or dissection.
  • Blood Pressure Control: Maintaining blood pressure within normal limits is critical, as even mild hypertension can accelerate the progression of aortic dissection.
  • Surgical Intervention: In cases where an aortic aneurysm or dissection is detected, surgical intervention may be required, which could involve aortic repair or replacement.

3. Genetic Counseling:

  • Inheritance Patterns: As Ehlers-Danlos Syndrome is an inherited disorder, genetic counseling is crucial for families, as it can provide valuable information regarding risks for future generations.
  • Prenatal Screening: In cases of known familial EDS, prenatal genetic testing may offer insights into the likelihood of passing on the condition.

Conclusion: The Imperative of Early Diagnosis and Comprehensive Care

Ehlers-Danlos Syndrome (Cutis Hyperelastica), while primarily a dermatological concern due to its striking impact on the skin’s elasticity, demands vigilant cardiovascular monitoring. The potential for Aortic Dissection, a life-threatening complication, underscores the need for comprehensive, multidisciplinary care. As we continue to advance our understanding of this complex disorder, it is essential to adopt a holistic approach to patient care, prioritizing both dermatologic and vascular health to optimize outcomes.

By drawing upon the expertise of leading specialists such as Dr. Gary Jayne Rothfeld, patients with Ehlers-Danlos Syndrome can receive the personalized, thorough care they need to manage this challenging condition and mitigate the risks associated with Aortic Dissection.



DR GARY JAYNE ROTHFELD

Darier’s Disease Treatment NYC | Dr. Gary Jayne Rothfeld, Board-Certified Dermatologist

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Darier’s Disease: The Unwanted Genetic Gift That Keeps on Giving

By Dr. Gary Jayne Rothfeld, Board-Certified Dermatologist

If dermatology were a Broadway production, Darier’s Disease (Keratosis Follicularis) wouldn’t be the star—more like the oddball supporting character that steals the scene for all the wrong reasons. This autosomal dominant mutation of the ATP2A2 gene is a rare, stubborn, and sometimes socially inconvenient disorder that prefers to announce its presence with greasy, wart-like lesions, foul-smelling bacterial tagalongs, and a general defiance to treatment—because why should anything in dermatology be easy?

And before you start blaming your diet, stress, or that one time you forgot to wash your pillowcase, let’s be clear: this is all genetic. If your parents handed you this ticket to the Darier’s Disease club, congratulations—you’ve got a VIP pass to chronic irritation.

Origins: Where Science Meets a Skin Tantrum

Discovered in 1889 by Ferdinand-Jean Darier—because, of course, no disease sounds more terrifying than when it’s named after a Frenchman—this condition arises from a defective calcium pump (ATP2A2 mutation). If that sounds boring, think of it this way: your skin cells are trying to build a brick wall, but instead of nice, orderly bricks, they’re stacking greasy potato chips held together with duct tape. Naturally, the epidermal barrier collapses, leading to fragile, crusty, warty papules that appear wherever your skin thinks you’ll find them most inconvenient—typically the chest, back, scalp, and forehead.

This isn’t some run-of-the-mill eczema or psoriasis—Darier’s Disease has a certain je ne sais quoi that sets it apart. While most dermatological conditions cycle through remission and flare-ups, Darier’s is like that one obnoxious guest at a party who just won’t leave and has way too much body odor.

Symptoms: If You’re Itchy and You Know It, Clap Your Hands

Patients of Dr. Gary Jayne Rothfeld—yes, Dr. Gary, as in the board-certified dermatologist at 629 Park Ave with four decades of experience treating the rarest of skin conditions—describe the following:

✅ Greasy, crusted papules – These seborrheic, hyperkeratotic lesions love the sebaceous zones (forehead, scalp, chest, upper back) and, left unchecked, can form larger, foul-smelling plaques.

✅ Fingernail abnormalities – If you enjoy neatly manicured nails, too bad. Expect longitudinal red and white streaks, V-shaped notches, and nail fragility. Even the finest salon in Manhattan can’t help.

✅ Oral papules – Not content with just your skin, Darier’s also decorates the roof of your mouth with whitish, cobblestone-like bumps.

✅ Odor you can’t ignore – Thanks to secondary bacterial colonization, the smell is less “fresh laundry” and more “week-old gym socks left in a sauna.”

✅ Heat and sweat intolerance – Because Darier’s hates summer more than a New Yorker stuck on the subway during rush hour, excessive heat or humidity can trigger an explosive flare-up.

✅ Viral susceptibility – HPV and herpes simplex viruses adore Darier’s lesions. Dr. Gary advises against direct skin trauma because—spoiler alert—it’s like rolling out a welcome mat for infections.

Diagnosis: The Art of Spotting Trouble

While a trained eye (like Dr. Gary’s) can diagnose Darier’s on sight, a skin biopsy confirms it. Under the microscope, you’ll find dyskeratosis, corps ronds, and grains, which sound like an artisanal French pastry but are actually histopathological markers of cellular mayhem.

Dr. Gary Jayne Rothfeld’s Treatment Plan

Now, Dr. Gary is not here to sell you snake oil or suggest rubbing kale on your lesions. Darier’s Disease requires a tailored, multi-faceted approach—because of course it does.

💊 Topical Retinoids (Tretinoin, Adapalene, Tazarotene) – The gold standard for mild cases. These derivatives of vitamin A promote cell turnover and help clear clogged follicular openings. But Dr. Gary warns: they can irritate already fragile skin, so use sparingly.

🧴 Antibiotics & Antiseptics – Erythromycin, clindamycin, or benzoyl peroxide can keep secondary infections under control. Because the last thing Darier’s needs is a bacterial plus-one.

💊 Oral Retinoids (Isotretinoin, Acitretin) – For severe, widespread cases, Dr. Gary might recommend these heavy hitters. But be warned: mucocutaneous dryness, teratogenic risks, and liver monitoring come with the territory.

☀️ Avoiding Heat, Humidity & UV Exposure – If Darier’s hates anything, it’s sweating, heat, and UV rays. Wear light, breathable clothing, slather on broad-spectrum sunscreen, and stay in the air conditioning like it’s a sacred temple.

The Darier’s Disease FAQ (or, “Dr. Gary, Please Just Fix This”)

💡 Is Darier’s Disease contagious?
No. You can’t spread a genetic mutation. That’s not how this works.

💡 Will it ever go away?
Sorry, no. But Dr. Gary can manage it, making it far less disruptive.

💡 Can lifestyle changes help?
Yes! Avoid sweating, stay cool, minimize friction, and use gentle skincare products.

💡 Who should treat Darier’s Disease?
A board-certified dermatologist with extensive experience in rare disorders—like Dr. Gary Jayne Rothfeld at 629 Park Ave, NYC.

Final Thoughts from Dr. Gary Jayne Rothfeld

If your skin is staging a rebellion, Dr. Gary Jayne Rothfeld is here to restore order. As a board-certified dermatologist with four decades of experience, an elite athlete who has represented the U.S. internationally in the metric mile, and now a Senior Olympian contender, Dr. Gary understands perseverance, precision, and performance—both in medicine and athletics.

📍 Visit Dr. Gary Jayne Rothfeld at 629 Park Ave, NYC
📞 Call 212-644-4484 to schedule your consultation
🌐 Website: nycdermatologist.com/dariers-disease-treatment-nyc

Because when it comes to rare skin diseases, you don’t just need a dermatologist. You need Dr. Gary.


DR GARY JAYNE ROTHFELD

Can Trauma Exacerbate Lipomas? Dr. Gary Rothfeld Explains Genetics, Trauma, and Non-Surgical Treatments

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Lipomas and Physical Trauma: The Hidden Impact of Your Daily Movements
By Dr. Gary Jayne Rothfeld

In the world of dermatology, there are few things more perplexing than a lipoma. These benign fatty growths tend to show up with little warning, often in places where you least expect them. But what if I told you that certain people—like professional baseball players or avid yogis—might be more prone to lipomas due to repetitive strain and physical trauma? That’s right. Those everyday movements, whether they’re the forceful motion of pitching a baseball or the stretching of the back during a deep yoga pose, can actually play a role in the formation of these pesky lumps.

You see, a lipoma forms when fat cells in the body grow abnormally and clump together in a small area beneath the skin. While the exact causes are still a bit mysterious, there’s no doubt that physical trauma and repetitive motion can have an influence on their development. As I, Dr. Gary Jayne Rothfeld, have seen time and time again, certain professions and activities subject the body to stress in ways that can lead to the creation of lipomas—or at the very least, exacerbate their growth.

Consider a professional baseball player. The repetitive motion of pitching, with its high-stress movements and frequent arm rotations, can lead to an unusual accumulation of fat cells in specific areas of the body. Over time, these repetitive motions can contribute to the formation of a lipoma, especially in the shoulder or upper arm area. The same is true for individuals who engage in high-intensity physical activity—like lifting weights or practicing yoga.

Let’s take yoga as an example. A woman who stretches deeply and regularly may notice a lipoma on her back or side. The stretching motion could pull and stretch the tissue surrounding the lipoma, causing it to expand, change shape, or become more pronounced. When the body is under consistent strain, especially in localized areas, the skin and underlying tissues may not be able to properly accommodate these changes, leading to the growth of lipomas.

So, what's going on beneath the surface? When the body is exposed to stress, it triggers inflammation as part of the healing process. Over time, this inflammation can lead to the development of lipomas, as fat cells proliferate in response to the trauma. While this doesn’t mean that every pitcher or yogi will develop lipomas, there is certainly an increased risk for those who subject specific body areas to repetitive strain.

For those of us who spend years training our bodies—whether it’s through swimming, lifting, or sports—lipomas can often be an unwelcome reminder that the body, despite its incredible resilience, isn't immune to the effects of constant stress. But don’t worry: just because you’re experiencing a lipoma doesn't mean you need to give up your passion or livelihood. The key is to identify and treat the lipomas early, which is where I, Dr. Gary Jayne Rothfeld, come in.

If you’ve developed a lipoma due to physical strain, don’t panic. While there is no surefire way to prevent them, there are treatment options available. For those of you who don’t want to be bothered by the presence of these growths, surgery is an option that can remove the lipoma with precision and minimal recovery time. Non-invasive treatments are also available for certain cases. The goal is not just to treat the lipoma, but to make sure you can continue living your life to the fullest—whether that means playing professional sports, practicing yoga, or simply enjoying a healthy, active lifestyle.

In my years of experience, I’ve treated many patients—athletes, yogis, and regular folks alike—who have come to me with concerns about lipomas related to repetitive trauma. And let me tell you this: lipomas don’t have to hold you back. I’ll work with you to come up with a plan to manage and remove those growths so that you can continue to push the limits of what your body is capable of.

So, for those of you who are wondering if your profession or passion is to blame for your lipomas—well, the answer is that it might be. But remember, lipomas don’t define you. And they certainly don’t stop you from being the best version of yourself. Whether it’s pitching that final strike or holding a perfect yoga pose, you’ve got more control over your body than you think. And I’ll be right here to help you take charge.


DR GARY JAYNE ROTHFELD